{"id":12732,"date":"2020-08-06T10:17:00","date_gmt":"2020-08-06T10:17:00","guid":{"rendered":"https:\/\/wordpress2.hdnweb.com\/2020\/08\/06\/hypomorphic-genetic-variants-associated-with-childhood-chronic-loose-stools\/"},"modified":"2020-08-06T10:17:00","modified_gmt":"2020-08-06T10:17:00","slug":"hypomorphic-genetic-variants-associated-with-childhood-chronic-loose-stools","status":"publish","type":"post","link":"https:\/\/wordpress2.hdnweb.com\/en\/2020\/08\/06\/hypomorphic-genetic-variants-associated-with-childhood-chronic-loose-stools\/","title":{"rendered":"Hypomorphic Genetic Variants Associated With Childhood Chronic Loose Stools"},"content":{"rendered":"<p><\/p>\n<style type=\"text\/css\"><![CDATA[\n\/* Style Definitions *\/\nspan.prnews_span\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\na.prnews_a\n{\ncolor:blue;\n}\nli.prnews_li\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\np.prnews_p\n{\nfont-size:0.62em;\nfont-family:\"Arial\";\ncolor:black;\nmargin:0in;\n}\n]]><\/style>\n<div class=\"xn-content\">\n<p><span class=\"xn-location\">VERO BEACH, Fla.<\/span>, <span class=\"xn-chron\">Aug. 6, 2020<\/span> \/PRNewswire\/ &#8212; QOL Medical, LLC today announced that <a target=\"_blank\" href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=en&amp;o=2877571-1&amp;h=1009761395&amp;u=https%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%2Fjournal.pone.0231891%23sec011&amp;a=PLoS+ONE\" rel=\"nofollow\">PLoS ONE<\/a> has published the results from a study of hypomorphic <i>SI<\/i> (sucrase-isomaltase) genetic variants known to cause Congenital Sucrase-Isomaltase Deficiency (CSID). The results show children with a hypomorphic <i>SI<\/i> variant had more serious gastrointestinal symptoms than those without.\u00a0 <\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<p>\n                        <a href=\"https:\/\/mma.prnewswire.com\/media\/591825\/QOL_Med_Logo.html\" target=\"_blank\" rel=\"nofollow\"><br \/>\n                    <img decoding=\"async\" src=\"https:\/\/mma.prnewswire.com\/media\/591825\/QOL_Med_Logo.jpg\" title=\"QOL Medical, LLC logo, 2017 (PRNewsfoto\/QOL Medical LLC)\" alt=\"QOL Medical, LLC logo, 2017 (PRNewsfoto\/QOL Medical LLC)\"\/><\/a>\n                <\/p>\n<\/p><\/div>\n<p>The 18-center study of 308 non-Hispanic white children was designed to assess the prevalence of CSID-associated <i>SI<\/i> variants relative to the general population and the gastrointestinal symptoms associated with a known <i>SI<\/i> genotype within the study population. <\/p>\n<p>Children with CSID, commonly known as Sucrose (sugar) Intolerance, have chronic diarrhea because they are unable to properly digest sucrose (table sugar), which is found in foods such as ice cream, apples, cake, and corn. <\/p>\n<p>In adolescents and adults, CSID has been characterized by symptoms of chronic loose stools and diarrhea, abdominal pain, gas, and periodic nausea, which overlap with common irritable bowel syndrome (IBS) symptoms. In infants, CSID classically presents as explosive watery diarrhea, failure to thrive, diaper rash, irritability, and acidic stools. <\/p>\n<p>&#8220;Results from this study reinforce the importance of testing children with chronic loose stools for CSID,&#8221; said <span class=\"xn-person\">Derick Cooper<\/span>, CEO of QOL Medical, LLC. &#8220;We are hopeful these findings will translate into more awareness and testing for pediatric patients who face daily challenges with this disease.&#8221;<\/p>\n<p>To review the full study, <a target=\"_blank\" href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=en&amp;o=2877571-1&amp;h=1786046191&amp;u=https%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%2Fjournal.pone.0231891%23sec011&amp;a=click+here\" rel=\"nofollow\">click here<\/a>: <\/p>\n<p>Currently, Sucraid<sup>\u00ae<\/sup> (sacrosidase) Oral Solution\u00a0is the only FDA-approved therapy for CSID in children and adults. Sucraid<sup>\u00ae<\/sup> is an enzyme replacement therapy for the treatment of genetically determined sucrase deficiency, which is part of Congenital Sucrase-Isomaltase Deficiency (CSID). Sucraid<sup>\u00ae<\/sup> can help improve the breakdown and absorption of sucrose (table sugar) from the intestine and can help relieve the gastrointestinal symptoms of CSID. <a target=\"_blank\" href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=en&amp;o=2877571-1&amp;h=3114038420&amp;u=http%3A%2F%2Fwww.sucraid.com%2F&amp;a=www.sucraid.com\" rel=\"nofollow\">www.sucraid.com<\/a><\/p>\n<p>Healthcare providers and patients can acquire Sucraid<sup>\u00ae<\/sup>\u00a0through US Bioservices Specialty Pharmacy at 800-705-1962. <\/p>\n<p><b>INDICATION<br \/><\/b>Sucraid<sup>\u00ae<\/sup>\u00a0(sacrosidase) Oral Solution is an enzyme replacement therapy for the treatment of genetically determined sucrase deficiency, which is part of Congenital Sucrase-Isomaltase Deficiency (CSID).\u00a0 <\/p>\n<p><b><u>IMPORTANT SAFETY INFORMATION FOR <\/u><\/b><b><u>SUCRAID<sup>\u00ae<\/sup><\/u><\/b><b><u>\u00a0(SACROSIDASE) ORAL SOLUTION<\/u><\/b><\/p>\n<ul type=\"disc\">\n<li>Sucraid<sup>\u00ae<\/sup> may cause a serious allergic reaction. If you notice any swelling or have difficulty breathing, get emergency help right away. <\/li>\n<li>Tell your doctor if you are allergic to, have ever had a reaction to, or have ever had difficulty taking yeast, yeast products, papain, or glycerin (glycerol). <\/li>\n<li>Sucraid<sup>\u00ae<\/sup> does not break down some sugars that come from the digestion of starch. You may need to restrict the amount of starch in your diet. Your doctor will tell you if you should restrict starch in your diet. <\/li>\n<li>Tell your doctor if you have diabetes, as your blood glucose levels may change if you begin taking Sucraid<sup>\u00ae<\/sup>. Your doctor will tell you if your diet or diabetes medicines need to be changed. <\/li>\n<li>Some patients treated with Sucraid<sup>\u00ae<\/sup>\u00a0may have worse abdominal pain, vomiting, nausea, or diarrhea. Constipation, difficulty sleeping, headache, nervousness, and dehydration have also occurred in patients treated with Sucraid<sup>\u00ae<\/sup>. Check with your doctor if you notice these or other side effects. <\/li>\n<li>Sucraid<sup>\u00ae<\/sup> has not been tested to see if it works in patients with secondary (acquired) sucrase deficiency. <\/li>\n<li><b>NEVER HEAT <\/b><b>SUCRAID<\/b><sup>\u00ae<\/sup>\u00a0<b>OR PUT IT IN WARM OR HOT BEVERAGES OR INFANT FORMULA. <\/b>Do not mix Sucraid<sup>\u00ae<\/sup> with fruit juice or take it with fruit juice. Take Sucraid<sup>\u00ae<\/sup> as prescribed by your doctor. Normally, half of the dose of Sucraid<sup>\u00ae<\/sup> is taken before a meal or snack and the other half is taken during the meal or snack.\u00a0 <\/li>\n<li>Sucraid<sup>\u00ae<\/sup> should be refrigerated at 36\u00b0F-46\u00b0F (2\u00b0C-8\u00b0C) and should be protected from heat and light.<\/li>\n<\/ul>\n<p><b>You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <\/b><a target=\"_blank\" href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=en&amp;o=2877571-1&amp;h=1549437368&amp;u=http%3A%2F%2Fwww.fda.gov%2Fmedwatch&amp;a=www.FDA.gov%2Fmedwatch\" rel=\"nofollow\"><b>www.FDA.gov\/medwatch<\/b><\/a><b>\u00a0or call 1-800-FDA-1088.<\/b><\/p>\n<p>Click here to read our full prescribing information: <a target=\"_blank\" href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=en&amp;o=2877571-1&amp;h=1877411490&amp;u=https%3A%2F%2Fwww.sucraid.com%2Fwp-content%2Fuploads%2F2019%2F12%2FSucPI_R0219.pdf&amp;a=Sucraid%C2%AE+PI\" rel=\"nofollow\">Sucraid<sup>\u00ae<\/sup> PI<\/a>.<\/p>\n<p><b>About QOL Medical, LLC<\/b><\/p>\n<p>QOL Medical is a specialty, biopharmaceutical company dedicated to improving clinical outcomes and overall quality of life for patients with rare diseases. QOL Medical is a patient-centric company founded in 2003 to focus on the acquisition and commercialization of orphan and gastrointestinal products in underserved markets. Learn more at <a target=\"_blank\" href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=en&amp;o=2877571-1&amp;h=2704770002&amp;u=http%3A%2F%2Fwww.qolmed.com%2F&amp;a=www.qolmed.com\" rel=\"nofollow\">www.qolmed.com<\/a>.<\/p>\n<p>Sucraid<sup>\u00ae<\/sup> is a registered trademark of QOL Medical, LLC. All rights reserved.<\/p>\n<p><b>Media Contact:<br \/>QOL Medical, LLC<br \/><\/b><span class=\"xn-person\">Tiffany Carter<\/span><br \/>Phone: 818-720-8557 <br \/>Email: <a target=\"_blank\" href=\"mailto:tiffany@tlcmarketingpr.com\" rel=\"nofollow\">tiffany@tlcmarketingpr.com<\/a><\/p>\n<p><b>Corporate Contact:<\/b><b><br \/>QOL Medical, LLC<\/b><br \/>3405 Ocean Drive<br \/><span class=\"xn-location\">Vero Beach, FL<\/span> 32963<br \/>Phone: 866-469-3773<br \/>Fax: 772-365-3375<br \/>Email: <a target=\"_blank\" href=\"mailto:info@qolmed.com\" rel=\"nofollow\">info@qolmed.com<\/a><\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2\">\n<\/div>\n<p id=\"PURL\"><img loading=\"lazy\" decoding=\"async\" title=\"Cision\" width=\"12\" height=\"12\" alt=\"Cision\" src=\"https:\/\/c212.net\/c\/img\/favicon.png?sn=LA83975&amp;sd=2020-08-06\"\/> View original content to download multimedia:<a id=\"PRNURL\" rel=\"nofollow\" href=\"http:\/\/www.prnewswire.com\/news-releases\/hypomorphic-genetic-variants-associated-with-childhood-chronic-loose-stools-301107647.html\">http:\/\/www.prnewswire.com\/news-releases\/hypomorphic-genetic-variants-associated-with-childhood-chronic-loose-stools-301107647.html<\/a><\/p>\n<p>SOURCE  QOL Medical, LLC<\/p>\n<\/div>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/rt.prnewswire.com\/rt.gif?NewsItemId=LA83975&amp;Transmission_Id=202008061017PR_NEWS_USPR_____LA83975&amp;DateId=20200806\" style=\"border:0px; width:1px; height:1px;\"\/> <\/p>","protected":false},"excerpt":{"rendered":"<div class=\"xn-content\">\n<p><span class=\"xn-location\">VERO BEACH, Fla.<\/span>, <span class=\"xn-chron\">Aug. 6, 2020<\/span> \/PRNewswire\/ &#8212; QOL Medical, LLC today announced that <a target=\"_blank\" href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=en&amp;o=2877571-1&amp;h=1009761395&amp;u=https%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%2Fjournal.pone.0231891%23sec011&amp;a=PLoS+ONE\" rel=\"nofollow noopener noreferrer\">PLoS ONE<\/a> has published the results from a study of hypomorphic <i>SI<\/i> (sucrase-isomaltase) genetic variants known to cause Congenital Sucrase-Isomaltase Deficiency (CSID). The&#8230;<\/p>\n","protected":false},"author":1,"featured_media":12733,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-12732","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-geovanny-vicente"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hypomorphic Genetic Variants Associated With Childhood Chronic Loose Stools - Multisitio 2<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wordpress2.hdnweb.com\/en\/2020\/08\/06\/hypomorphic-genetic-variants-associated-with-childhood-chronic-loose-stools\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hypomorphic Genetic Variants Associated With Childhood Chronic Loose Stools - Multisitio 2\" \/>\n<meta property=\"og:description\" content=\"VERO BEACH, Fla., Aug. 6, 2020 \/PRNewswire\/ -- QOL Medical, LLC today announced that PLoS ONE has published the results from a study of hypomorphic SI (sucrase-isomaltase) genetic variants known to cause Congenital Sucrase-Isomaltase Deficiency (CSID). 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