{"id":14468,"date":"2020-08-07T15:21:00","date_gmt":"2020-08-07T15:21:00","guid":{"rendered":"https:\/\/wordpress2.hdnweb.com\/2020\/08\/07\/fda-approves-first-liquid-biopsy-next-generation-sequencing-companion-diagnostic-test\/"},"modified":"2020-08-07T15:21:00","modified_gmt":"2020-08-07T15:21:00","slug":"fda-approves-first-liquid-biopsy-next-generation-sequencing-companion-diagnostic-test","status":"publish","type":"post","link":"https:\/\/wordpress2.hdnweb.com\/en\/2020\/08\/07\/fda-approves-first-liquid-biopsy-next-generation-sequencing-companion-diagnostic-test\/","title":{"rendered":"FDA Approves First Liquid Biopsy Next-Generation Sequencing Companion Diagnostic Test"},"content":{"rendered":"<p><\/p>\n<style type=\"text\/css\"><![CDATA[\n\/* Style Definitions *\/\nspan.prnews_span\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\na.prnews_a\n{\ncolor:blue;\n}\nli.prnews_li\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\np.prnews_p\n{\nfont-size:0.62em;\nfont-family:\"Arial\";\ncolor:black;\nmargin:0in;\n}\n.prntac{\nTEXT-ALIGN: CENTER\n}\n]]><\/style>\n<div class=\"xn-content\">\n<p><span class=\"xn-location\">SILVER SPRING, Md.<\/span>, <span class=\"xn-chron\">Aug. 7, 2020<\/span> \/PRNewswire\/ &#8212; Today, the U.S. Food and Drug Administration approved the first liquid biopsy companion diagnostic that also uses next-generation sequencing (NGS) technology to identify patients with specific types of mutations of the epidermal growth factor receptor (EGFR) gene in a deadly form of metastatic non-small cell lung cancer (NSCLC). This is the first approval to combine two technologies \u2014 NGS and liquid biopsy \u2014 in one diagnostic test in order to guide treatment decisions.<\/p>\n<p><b>&#8220;Approval of a companion diagnostic that uses a liquid biopsy and leverages next-generation sequencing marks a new era for mutation testing,&#8221; said <span class=\"xn-person\">Tim Stenzel<\/span>, M.D., Ph.D., director of the Office of In Vitro Diagnostics and Radiological Health in the FDA&#8217;s Center for Devices and Radiological Health. \u00a0<\/b><b>&#8220;In addition to benefitting from less invasive testing, patients are provided with a simultaneous mapping of multiple biomarkers of genomic alterations, rather than one biomarker at a time, which can translate to decreased wait times for starting treatment and provide insight into possible resistance mechanisms.&#8221;<\/b><\/p>\n<p>The Guardant360 CDx assay utilizes two technologies. The first is called liquid biopsy, which uses a blood sample to provide health care professionals with genetic information about the patient&#8217;s tumor. It is less invasive and more easily repeatable in comparison to standard tissue biopsies. Furthermore, liquid biopsy tests can be used in cases in which standard tissue biopsies are not feasible, for instance, due to the location of the tumor.<\/p>\n<p>The second technology is NGS, which uses large-panel genetic sequencing, known as high-throughput tumor profiling. Compared to older technologies that required multiple tests, NGS requires only one test and allows clinicians to better assess tumor composition, giving providers an advantage in evaluating which mutations are problematic. The Guardant360 CDx assay uses NGS technology to simultaneously detect mutations in 55 tumor genes, rather than one gene at a time.<\/p>\n<p>While the Guardant360CDx can provide information on multiple solid tumor biomarkers, today&#8217;s approval is specific to its use in identifying EGFR mutations in patients who will benefit from treatment with TAGRISSO (osimertinib), an FDA-approved therapy for a form of metastatic NSCLC. Lung cancer is the leading cause of cancer-related death among men and women in <span class=\"xn-location\">the United States<\/span>, and NSCLC is the most common type of lung cancer. Genomic findings for other biomarkers evaluated are not validated for choosing a particular corresponding treatment with this approval. If the specific NSCLC mutations associated with today&#8217;s approval are not detected in the blood, then a tumor biopsy should be performed to determine if the NSCLC mutations are present.<\/p>\n<p>The Guardant360 CDx assay was granted a Breakthrough Device designation, in which the FDA provides intensive interaction and guidance to the company on efficient device development.<\/p>\n<p>The FDA granted approval for the Guardant360 CDx test to Guardant Health.<\/p>\n<p><b>Media Contact:<\/b>\u00a0<a target=\"_blank\" href=\"mailto:kristin.jarrell@fda.hhs.gov\" rel=\"nofollow\"><span class=\"xn-person\">Kristin Jarrell<\/span><\/a>, 301-796-0137 <br \/><b>Consumer Inquiries<\/b>: <a target=\"_blank\" href=\"mailto:DRUGINFO@fda.hhs.gov\" rel=\"nofollow\">Email<\/a>\u00a0or 888-INFO-FDA<\/p>\n<p class=\"prntac\"><i>The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The agency also is responsible for the safety and security of our nation&#8217;s food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products.<\/i><\/p>\n<p>\u00a0<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder7543\">\n<p><a href=\"https:\/\/mma.prnewswire.com\/media\/317925\/FDA_Logo.html\" target=\"_blank\" rel=\"nofollow\"><img decoding=\"async\" src=\"https:\/\/mma.prnewswire.com\/media\/317925\/FDA_Logo.jpg\" title=\"U.S. Food and Drug Administration (FDA) logo (PRNewsfoto\/FDA)\" alt=\"U.S. Food and Drug Administration (FDA) logo (PRNewsfoto\/FDA)\"\/><\/a><\/p>\n<\/div>\n<p>\u00a0<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">\n<\/div>\n<p id=\"PURL\"><img loading=\"lazy\" decoding=\"async\" title=\"Cision\" width=\"12\" height=\"12\" alt=\"Cision\" src=\"https:\/\/c212.net\/c\/img\/favicon.png?sn=PH86501&amp;sd=2020-08-07\"\/> View original content to download multimedia:<a id=\"PRNURL\" rel=\"nofollow\" href=\"http:\/\/www.prnewswire.com\/news-releases\/fda-approves-first-liquid-biopsy-next-generation-sequencing-companion-diagnostic-test-301108536.html\">http:\/\/www.prnewswire.com\/news-releases\/fda-approves-first-liquid-biopsy-next-generation-sequencing-companion-diagnostic-test-301108536.html<\/a><\/p>\n<p>SOURCE  U.S. Food and Drug Administration<\/p>\n<\/div>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/rt.prnewswire.com\/rt.gif?NewsItemId=PH86501&amp;Transmission_Id=202008071521PR_NEWS_USPR_____PH86501&amp;DateId=20200807\" style=\"border:0px; width:1px; height:1px;\"\/> <\/p>","protected":false},"excerpt":{"rendered":"<div class=\"xn-content\">\n<p><span class=\"xn-location\">SILVER SPRING, Md.<\/span>, <span class=\"xn-chron\">Aug. 7, 2020<\/span> \/PRNewswire\/ &#8212; Today, the U.S. Food and Drug Administration approved the first liquid biopsy companion diagnostic that also uses next-generation sequencing (NGS) technology to identify patients with specific types of mutations of the epidermal growth factor receptor (EGFR) gene in a deadly form of metastatic non-small cell lung cancer (NSCLC). This is the first approval to combine two technologies \u2014 NGS and liquid biopsy \u2014 in one diagnostic test in order to guide&#8230;<\/p>\n","protected":false},"author":1,"featured_media":14469,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-14468","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-geovanny-vicente"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>FDA Approves First Liquid Biopsy Next-Generation Sequencing Companion Diagnostic Test - Multisitio 2<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wordpress2.hdnweb.com\/en\/2020\/08\/07\/fda-approves-first-liquid-biopsy-next-generation-sequencing-companion-diagnostic-test\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FDA Approves First Liquid Biopsy Next-Generation Sequencing Companion Diagnostic Test - Multisitio 2\" \/>\n<meta property=\"og:description\" content=\"SILVER SPRING, Md., Aug. 7, 2020 \/PRNewswire\/ -- Today, the U.S. Food and Drug Administration approved the first liquid biopsy companion diagnostic that also uses next-generation sequencing (NGS) technology to identify patients with specific types of mutations of the epidermal growth factor receptor (EGFR) gene in a deadly form of metastatic non-small cell lung cancer (NSCLC). 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