Biosynthetic Technologies Receives Provisional AEGIR-Marine Approval For Its Biobased Biosynthetic® VGP Compliant ISO 68 Hydraulic Fluid

INDIANAPOLIS, Feb. 2, 2021 /PRNewswire/ — Biosynthetic® Technologies today announced it has been awarded the provisional AEGIR-Marine approval for its Biosynthetic® ISO 68 hydraulic fluid specifically manufactured for marine applications.

INDIANAPOLIS, Feb. 2, 2021 /PRNewswire/ — Biosynthetic® Technologies today announced it has been awarded the provisional AEGIR-Marine approval for its Biosynthetic® ISO 68 hydraulic fluid specifically manufactured for marine applications.

Biosynthetic Technologies has developed a novel class of high-performance, bio-based base oils for the use in finished lubricants.  These base oils utilize the patented estolide technology and are biobased, biodegradable, non-bioaccumulative, and non-toxic. To showcase the efficacy and superior performance characteristics of these base oils, Biosynthetic Technologies has developed an ISO 68 marine hydraulic fluid that is sustainable, biobased, and VGP compliant. The patented estolide technology enhances the lubricity, demulsibility, film strength, hydrolytic stability, and oxidative stability of the lubricant and enhances seal compatibility as well; the perfect combination for demanding marine lubricant applications. 

«We are proud to report that our biobased, VGP compliant marine hydraulic fluid has received provisional AEGIR-Marine approval, indicating that AEGIR‘s Prime seals and Biosynthetic Technologies’ lubricants are compatible,» said Dr. Matt Kriech, COO of Biosynthetic Technologies.

AEGIR-Marine’s static compatibility tests found compatibility between the Prime seals Biosynthetic ISO 68 Hydraulic Fluid lubricant. «Meeting our focus of innovations for a sustainable future , receiving AEGIR-Marine approval for our VGP compliant marine lubricants is key to the successful integration of our base oils into the development and manufacture of  Environmentally Acceptable Lubricants (EAL) formulations worldwide.» Said Mr. Mark Miller, CEO of Biosynthetic Technologies. «Our sustainable base oils deliver superior performance, especially in the areas of lubricity, oxidative stability and hydrolytic stability as well as wear performance, providing the market with a high performance alternative to petroleum derived lubricants.»

At Biosynthetic Technologies, we understand the importance of sustainable manufacturing practices. Biosynthetic Technologies is committed to sustainability and clearly focused on the responsible use of natural resources in our daily business. We understand that health, environmental awareness and traceability play just as large a role for consumers as quality and efficacy. Biosynthetic Technologies is aware of its responsibility in this business and sustainability. As such, our manufacturing facility is operating with a NEGATIVE carbon footprint!

About Biosynthetic® Technologies:
Biosynthetic® Technologies manufactures a revolutionary new class of biobased synthetic compounds called Estolides that are made from organic fatty acids found in various bio-derived oils. These highly functional biosynthetic oils have numerous uses in lubricant, automotive, marine, pharma and personal care applications and can be used as the primary base oil of a formulation, a component of a base oil co-blend, or even as an additive. In addition to their high-performance properties, these renewable oils are biodegradable and nontoxic. Biosynthetic Technologies strives to make their mark on the world by delivering innovations for a sustainable future. For more information about Biosynthetic™ Technologies, please visit www.biosynthetic.com and follow us on LinkedIn.

About AEGIR-Marine
AEGIR-Marine is a full service provider for stern tube seals and propulsion systems for the maritime industry. The company focuses on exceptional quality service for both ship owners and ship managers. AEGIR-Marine was established in 2000. Since then the company managed to become a major supplier of independent maritime services for all main maritime propulsion systems. AEGIR-Marine’s headquarters are located in Wijk bij Duurstede, the Netherlands. The company also has offices in Namibia, Singapore, Dubai, China and the USA from where Service Engineers can be dispatched globally. Besides its offices, AEGIR-Marine works with a network of professional agents. From Canada to Chile, from Indonesia to Sweden and from Greece to Japan. More information is available via www.aegirmarine.com.

 

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SOURCE Biosynthetic Technologies

Greentown Labs Houston Celebrates New Partners at Reveal Ceremony on Feb. 2

SOMERVILLE, Mass. and HOUSTON, Feb. 2, 2021 /PRNewswire/ — Greentown Labs Houston (Greentown Houston), the city’s first-ever climatetech startup incubator, today announced its network of partners has grown by five with the addition of <a target="_blank"…

SOMERVILLE, Mass. and HOUSTON, Feb. 2, 2021 /PRNewswire/ — Greentown Labs Houston (Greentown Houston), the city’s first-ever climatetech startup incubator, today announced its network of partners has grown by five with the addition of CenterPoint Energy, Gexa Energy of NextEra Energy Resources, EIV Capital, Wells Fargo, and Williams as its newest Founding and Grand Opening Partners. These partners join a diverse group of 16 existing partners that represent a broad community of energy organizations, renewable energy experts, and organizations committed to supporting early-stage cleantech startups.

«Greentown Houston is proud to have CenterPoint Energy, Gexa Energy, EIV Capital, Wells Fargo, and Williams join our roster of partners that are committed to climate action and accelerating the deployment of climatetech solutions,» said Dr. Emily Reichert, CEO of Greentown Labs. «These partners—from energy providers to financial services organizations—will play a pivotal role in enabling the success of both our operations and the Houston startup community.»

In September 2020, Greentown Houston announced its location at 4200 San Jacinto St. in the Innovation District being developed by Rice Management Company. The general contractor for the project is Miller LaPoint Construction, based in Houston. Design services for the project are provided by Abel Design Group and Silverman Trykowski Architects. The incubator will provide more than 40,000 sq. ft. of prototyping lab, office, and community space for about 50 startup companies, totaling 200-300 employees.

At a celebratory ceremony alongside Houston Mayor Sylvester Turner on Feb. 2, Greentown Houston will reveal what the exterior facade of the building and interior layout will look like once it opens. The building’s exterior will be painted gray with Greentown Labs’ brand colors incorporated as accent details. Greentown Houston is working with the Houston Arts Alliance to identify a local artist to install a large mural on the east side of the building to display Greentown Houston’s mission around climate action, community collaboration, and entrepreneurial partnership.

In light of COVID-19 restrictions, the Feb. 2 ceremony is private but interested parties can view images and footage of Greentown Houston here, and all are invited to a public, virtual EnergyBar networking event on Feb. 4 at 4 p.m. CT / 5 p.m. ET., where attendees can hear a recap of the Feb. 2 ceremony, learn about Greentown Houston’s progress, and get a sneak peek of what the incubator will look like when it opens this spring.

«Houston is delighted to welcome Greentown Labs to our expanding innovation ecosystem, and we can’t wait to see the incubator’s facility open in a few short months,» said Mayor Sylvester Turner. «Last year, we released our first-ever Climate Action Plan, and we believe organizations like Greentown Labs, its impressive network of partners, and climatetech entrepreneurs will help us achieve the ambitious goals outlined in the plan. The City of Houston is focused on catalyzing and leading the global energy transition, and we’re excited to work with Greentown Labs on this effort.»  

Greentown Houston is a proud member of the Greater Houston Partnership and is actively involved in the organization’s economic development efforts to help Houston lead the global energy transition. 

«It is essential that we position Houston as the leader of the global energy transition, and Greentown Houston is a crucial part of that effort,» said Susan Davenport, Chief Economic Development Officer with the Greater Houston Partnership. «We are thrilled to join Greentown Houston to celebrate this critical step forward in their much-anticipated expansion with the addition of these new partners. These organizations, and the expertise and resources they bring, join a thriving ecosystem built of major corporate energy R&D centers, corporate venture arms, and VC-backed energy startups. We are eagerly anticipating Greentown Houston’s official opening this spring and look forward to working together to build a more efficient and more sustainable low-carbon future.»

Greentown Houston sits adjacent to The Ion, a 288,000 sq. ft. innovation hub that anchors the Innovation District being developed by Rice Management Company.

«We are excited to recognize Greentown Houston’s momentum. This is another step in solidifying Greentown’s presence as Houston’s premier destination for cleantech and climate change technology,» said Ryan LeVasseur, Managing Director of Direct Real Estate at Rice Management Company. «Greentown’s role in the innovation ecosystem further solidifies the Innovation District’s position as a hub for the advancement of the region’s economy. Together, The Ion and Greentown Houston will set a new standard for creating new opportunities for innovators and entrepreneurs.»

Greentown Houston’s Growing Partner Network

Since announcing its expansion to Houston in June 2020, Greentown Labs has received a warm welcome from the Houston business community—underscoring the city’s eagerness and enthusiasm to lead the energy transition. Today, Greentown Houston is fortunate to welcome three new Founding Partners to its ecosystem:

As the only investor-owned electric and gas utility based in Texas, CenterPoint Energy, Inc. (NYSE: CNP) is an energy delivery company with electric transmission and distribution, power generation, and natural gas distribution operations that serve more than 7 million metered customers in Arkansas, Indiana, Louisiana, Minnesota, Mississippi, Ohio, Oklahoma, and Texas. As of Sept. 30, 2020, the company owned approximately $33 billion in assets and also owned 53.7 percent of the common units representing limited partner interests in Enable Midstream Partners, LP, a publicly traded master limited partnership that owns, operates, and develops strategically located natural gas and crude oil infrastructure assets. With approximately 9,600 employees, CenterPoint Energy and its predecessor companies have been in business for more than 150 years.  

«At CenterPoint Energy, we are energized by this partnership with Greentown Labs. Our company has a strong commitment to the delivery of clean energy to customers and we see this partnership as an opportunity to lend our expertise and industry knowledge to help craft and accelerate a clean energy future,» said Kenny Mercado, Executive Vice President of Electric Utility at CenterPoint Energy. «As part of our new long-term growth strategy, we plan to provide a modern, reliable electric grid to connect the large number of renewable energy projects being built in our Houston service territory. We are also committed to the continued development of alternative fuels programs, including renewable natural gas, that would provide customers new energy choices.»

Gexa Energy, a wholly owned subsidiary of NextEra Energy Resources, is one of the fastest-growing retail electricity providers in the U.S., serving over 1.5 million residential and commercial customers. NextEra Energy Resources is one of the largest wholesale generators of electric power in the nation and the largest generator of renewable energy from the wind and sun in the world.

«Greentown Labs is an exciting forum for Gexa Energy to collaborate and accelerate early stage innovation. We look forward to developing new ideas in Houston that benefit our customers and the broader markets,» said Brian Landrum, President at Gexa Energy.

Wells Fargo is a leading financial services company that has approximately $1.9 trillion in assets and proudly serves one in three U.S. households and more than 10 percent of all middle-market companies in the U.S. Wells Fargo is committed to playing an important role in accelerating a just transition to a low-carbon economy and reducing the impacts of climate change. Through strategic partnerships, its goal is to do this by increasing its operational efficiency, advancing clean technology, innovation, and other environmental solutions—at work, at home, and in the communities it serves.

«Wells Fargo is committed to bringing innovation and entrepreneurship to Houston,» said Chad Johnson, Senior Vice President at Wells Fargo’s Technology Banking Group. «This is an exciting time to see Houston’s tech ecosystem expand and become home to cleantech incubators. We know Greentown Labs will provide critical resources to entrepreneurs that will enable them to launch innovative businesses, which will help build a more sustainable future for our city.»

Greentown Houston is on schedule to open its facility in Spring 2021, and has a subset of partners dedicated to the success of its grand opening. Naturgy and FCC Environmental Services (FCC) were the first Greentown Houston Grand Opening Partners and today EIV Capital and Williams join them.

EIV Capital, a Houston-based private equity firm, specializes in providing growth equity to the North American energy industry. EIV concentrates on midstream infrastructure, emissions management, and alternative energy. The firms’ management has extensive experience leading and investing in successful companies across the energy value chain, including companies focused on carbon reduction.

«EIV Capital is proud to support Greentown Labs and welcomes them to Houston. We believe fostering collaboration between Greentown Labs’ climatetech and cleantech entrepreneurs and Houston’s world-leading energy community is essential to developing and scaling the solutions needed to address climate change while still providing affordable and reliable energy,» said Patti Melcher, Co-founder & Managing Partner of EIV Capital. «We are committed to Greentown Labs’ mission and pleased to be joining a robust and collaborative partner network that will ensure its success.»

Williams, an industry-leading energy infrastructure company, is committed to the safe delivery of natural gas products to reliably fuel the clean energy economy in the United States. Williams manages 30 percent of the nation’s natural gas used for clean-power generation, heating, and industrial use. In 2020, Williams announced ambitious climate commitments, aiming to reduce 56 percent of company-wide greenhouse gas emissions by 2030, and is on a pathway to net zero emissions by 2050.

«Williams is excited to join Greentown Labs as the first midstream corporate partner to support cleantech entrepreneurship that will accelerate the transition to a low-carbon future,» said Chad Zamarin, Senior Vice President of Corporate Strategic Development at Williams. «It is through technology innovation and collaboration with organizations like Greentown Labs that we can develop solutions to reduce emissions and build a clean energy economy on our path to net zero by 2050.» 

In 2020, Greentown Labs was thrilled to announce its 14 inaugural Houston Founding Partners: Chevron, NRG Energy and Reliant Energy, Shell, BHP, Vinson & Elkins, Microsoft, ENGIE North America Inc., Rice Management Company, Saint-Gobain, Sunnova Energy International Inc., The American Family Insurance Institute for Corporate and Social Impact, SCF Partners, Tudor, Pickering, Holt & Co., and Direct Energy 

Greentown Houston recently announced its 16 inaugural startup members. It is actively accepting startup members through its early access membership offering and welcoming additional partners in advance of the facility opening in Spring 2021. Interested startups and prospective partners should reach out via this form.

About Greentown Labs
Greentown Labs is a community of climatetech and cleantech pioneers working to design a more sustainable world. As the largest climatetech startup incubator in North America, Greentown Labs brings together startups, corporates, investors, policymakers, and many others with a focus on scaling climate solutions. Driven by the mission of providing ground-breaking startups the resources, knowledge, connections, and equipment they need to thrive, Greentown Labs offers prototyping and wet lab space, shared office space, a machine shop, an electronics lab, software and business resources, a large network of corporate customers and investors, and more. Greentown Labs’ 100,000 sq. ft. campus in Somerville, Mass. is home to more than 100 startups and has supported more than 300 startups since the incubator’s founding in 2011. These startups have collectively created more than 6,500 direct jobs and have raised more than $1.2 billion in funding. For more information, please visit www.greentownlabs.com or Twitter, Facebook, and LinkedIn.

Greentown Labs Media Contact:
Julia Travaglini
VP of Marketing & Communications
julia@greentownlabs.com
603-867-3657

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SOURCE Greentown Labs

Following December Decline, Small Business Employment Growth Holds Steady in January

ROCHESTER, N.Y., Feb. 2, 2021 /PRNewswire/ — The latest Paychex | IHS Markit Business Employment Watch report is out. The…

ROCHESTER, N.Y., Feb. 2, 2021 /PRNewswire/ — The latest Paychex | IHS Markit Business Employment Watch report is out. The January numbers show the national Small Business Jobs Index held relatively stable from the previous month, moderating slightly to 94.00 or 0.07 percent. Both the growth in earnings and hours worked are trending higher to begin the year following a six-month slowdown. Hourly earnings growth increased to 2.68 percent. Weekly earnings growth also increased to 2.84 percent as weekly hours worked rose 0.17 percent.

«After December’s decline, the Small Business Jobs Index remained relatively flat in January,» said James Diffley, chief regional economist at IHS Markit.

«Led by a strong showing in construction, most industries experienced gains in January. This helped stabilize employment growth to begin the year,» said Martin Mucci, Paychex president and CEO. «The new round of Paycheck Protection Program loans will be especially important to businesses negatively impacted by COVID-19. Especially those in the hospitality sector where the maximum loan amount has been increased.»

The monthly report, widely considered an industry benchmark, draws payroll data of approximately 350,000 Paychex clients to gauge small business wage and employment trends on a national, regional, state, metro, and industry basis.

In further detail, the January report showed:

  • Five of the eight industry sectors analyzed experienced job growth in January.
  • Losses were concentrated in leisure and hospitality, which declined 0.63 percent from the previous month.
  • Job growth was most robust in the construction industry, which increased 0.34 percent.
  • California climbed four spots in the state rankings, spurred by the construction industry, and saw its best one-month increase in eleven years.
  • The South leads in small business job growth, more than a point ahead of all other regions.
  • Florida, Texas, and Tennessee are the only states with jobs index levels above 96.
  • Following a six-month slowdown, both the growth in earnings and hours worked are trending higher.
  • 15 of the 20 states analyzed have positive year-over-year weekly hours worked growth.

The complete results for January, including interactive charts detailing all data at a national, regional, state, metro, and industry level, are available at www.paychex.com/watch. Highlights are available below. 

Note: Data presented for the month of January was collected between December 18, 2020 and January 21, 2021.

National Jobs Index

  • At 94.00, the Small Business Jobs Index moderated slightly from the previous month, down 0.07 percent.
  • The national index is down 4.25 from January 2020.

National Wage Report

  • Both earnings and hours worked growth are moving higher to begin 2021 following a six-month slowdown.
  • Hourly earnings growth increased in January to 2.68 percent.
  • Weekly earnings growth increased 2.84 percent, a reversal of its recent downward trend. One-month annualized growth stood at its highest level since June 2020.

Regional Jobs Index

  • The West had its most significant one-month increase, driven by gains in the construction industry, in more than eight years. All other regions decreased.
  • The South leads in small business job growth, more than a point ahead of all other regions.
  • The Northeast fell to last among regions, with job growth slowing by 0.29 percent in January.

Regional Wage Report 

  • At 3.69 percent, the Northeast ranks first among regions in hourly earnings growth.
  • Down 0.45 percent year-over-year, the South is the only region with a contraction in weekly hours worked.
  • Hourly earnings growth has been below two percent in the South for the past quarter, the first time this has happened since 2018. 

State Jobs Index

  • California climbed four spots in the state rankings, on the back of its best one-month increase in eleven years. The gain was spurred by the construction industry, driving the index to 93.32
  • Florida, Texas, and Tennessee are the only states with index levels above 96.
  • Maryland is the weakest in one-month growth among all states. A -1.02 percent growth rate pushed it down seven spots.

Note: Analysis is provided for the 20 largest states based on U.S. population.

State Wage Report

  • New Jersey, followed by Massachusetts and Pennsylvania, leads all states in hourly earnings growth, above four percent in January.
  • Aided by consistently positive weekly hours worked growth during the past year, weekly earnings in Michigan increased to 5.11 percent, leading all states in January.
  • 15 of the 20 states analyzed have positive year-over-year weekly hours worked growth, with Wisconsin (1.01 percent), Michigan (0.73 percent), and New York (0.61 percent) leading all states.

Note: Analysis is provided for the 20 largest states based on U.S. population.

Metropolitan Jobs Index 

  • The Dallas metro area returns as the highest-ranking for small business employment growth to begin 2021. It previously held the top spot for all of 2019.
  • San Francisco fell 0.45 percent to 91.23 in January and is down more than six percent year-over-year, ahead of only Seattle.
  • The Denver metro area tumbled 2.27 percent during the past quarter, ranking it fourth among metros. It previously was first among metros from July to November.

Note: Analysis is provided for the 20 largest metro areas based on U.S. population.

Metropolitan Wage Report

  • At 5.76 percent, Riverside, CA leads metros in hourly earnings growth, with only one other metro above four percent (Boston at 4.46 percent).
  • Hourly earnings growth in San Francisco is below two percent, at 1.74, while Los Angeles, San Diego, and Riverside are above three percent.
  • Houston, Miami, and Atlanta are all down more than one percent in weekly hours worked growth.

Note: Analysis is provided for the 20 largest metro areas based on U.S. population.

Industry Jobs Index

  • Almost all industry sectors demonstrated month-over-month stability. The lagging industries included leisure and hospitality.
  • As a result of increased COVID-19 shutdowns across the country, leisure and hospitality fell 0.63 percent in January to 86.53 and is now down 10.96 percent year-over-year.
  • The housing market boom lifted the construction industry in January by 0.34 percent. Construction continues to lead sectors in small business employment growth.

Note: Analysis is provided for seven major industry sectors. Definitions of each industry sector can be found here. The Other Services (excluding Public Administration) industry category includes religious, civic, and social organizations, as well as personal services, including automotive and household repair, salons, drycleaners, and other businesses.

Industry Wage Report 

  • Similar to results seen in the Small Business Jobs Index, construction ranks first among industries in earnings and hours worked growth.
  • Weekly earnings growth in leisure and hospitality is down 2.47 percent in January, as the three-month annualized growth rate is down more than ten percent.
  • Trade, transportation, and utilities follow construction as the only sector with hourly earnings growth above three percent.

Note: Analysis is provided for seven major industry sectors. Definitions of each industry sector can be found here. The Other Services (excluding Public Administration) industry category includes religious, civic, and social organizations, as well as personal services, including automotive and household repair, salons, drycleaners, and other businesses.

For more information about the Paychex | IHS Markit Small Business Employment Watch, visit www.paychex.com/watch and sign up to receive monthly Employment Watch alerts.

*Information regarding the professions included in the industry data can be found at the Bureau of Labor Statistics website.

About the Paychex | IHS Markit Small Business Employment Watch
The Paychex | IHS Markit Small Business Employment Watch is released each month by Paychex, Inc., a leading provider of payroll, human resource, insurance, and benefits outsourcing solutions for small-to medium-sized businesses, and IHS Markit, a world leader in critical information, analytics, and expertise. Focused exclusively on small business, the monthly report offers analysis of national employment and wage trends, as well as examines regional, state, metro, and industry sector activity. Drawing from the payroll data of approximately 350,000 Paychex clients, this powerful tool delivers real-time insights into the small business trends driving the U.S. economy.

About Paychex
Paychex, Inc. (NASDAQ:PAYX) is a leading provider of integrated human capital management solutions for payroll, benefits, human resources, and insurance services. By combining its innovative software-as-a-service technology and mobility platform with dedicated, personal service, Paychex empowers small- and medium-sized business owners to focus on the growth and management of their business. Backed by more than 45 years of industry expertise, Paychex served more than 680,000 payroll clients as of May 31, 2020 across more than 100 locations in the U.S. and Europe, and pays one out of every 12 American private sector employees. Learn more about Paychex by visiting paychex.com and stay connected on Twitter and LinkedIn.

About IHS Markit (www.ihsmarkit.com)
IHS Markit (NYSE: INFO) is a world leader in critical information, analytics and solutions for the major industries and markets that drive economies worldwide. The company delivers next-generation information, analytics and solutions to customers in business, finance and government, improving their operational efficiency and providing deep insights that lead to well-informed, confident decisions. IHS Markit has more than 50,000 business and government customers, including 80 percent of the Fortune Global 500 and the world’s leading financial institutions. Headquartered in London, IHS Markit is committed to sustainable, profitable growth.

IHS Markit is a registered trademark of IHS Markit Ltd. and/or its affiliates. All other company and product names may be trademarks of their respective owners © 2021 IHS Markit Ltd. All rights reserved.

Media Contacts
Lisa Fleming
Paychex, Inc.
+1 585-387-6402
lfleming@paychex.com 
@PaychexNews 

Kate Smith
IHS Markit
+1 781-301-9311
katherine.smith@ihsmarkit.com 

Colleen Bennis
Mower
+1 585-389-1865
cbennis@mower.com 

 

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SOURCE Paychex, Inc.

Veterans for Responsible Leadership Speaks Out Against Violent Extremism in the Ranks

DENVER, Feb. 2, 2021 /PRNewswire/ — Veterans for Responsible Leadership (VFRL), a nonpartisan organization representing veterans from many eras, today condemned the behavior of current and former military personnel who were reported to make up a disproportionate number of those arrested for participation in the…

DENVER, Feb. 2, 2021 /PRNewswire/ — Veterans for Responsible Leadership (VFRL), a nonpartisan organization representing veterans from many eras, today condemned the behavior of current and former military personnel who were reported to make up a disproportionate number of those arrested for participation in the deadly events at the US Capitol on January 6th.  The 14% of reported arrests who are military members or veterans included a member of the so-called «Proud Boys» and Army veteran Joseph Randall Briggs, retired Air Force officer Larry Brock, former Marine and current national guardsman Jacob Fracker, and Timothy Louis Hale-Cusanelli, an Army reserve NCO, all of whom are reported to have actively participated in the violent extremism demonstrated at the nation’s Capitol on January 6. 

«Participation in the insurrection on January 6 by any current or former service member was a violation of their oath.  This includes anyone who actively encouraged this horrendous attack on our democracy,» said Dr. Daniel Barkhuff, VFRL president and former Navy SEAL. «None of these actions reflect US military values.  We urge our fellow veterans to remember their oath and steer clear of this dark road.» 

According to widespread news reports and court documents, all four men entered the Capitol in violation of federal law.  Images appear to show Brock breaching the Senate Chambers wearing a combat helmet and carrying zip ties. Briggs is reported to have encouraged «Proud Boy» participation before and during the insurrection. 

«This is a stain on the entire military community.  We need to do more to confront the forces and pull of extremism that plague our ranks,» Dr. Barkhuff said. 

VFRL’s members believe that the vast majority of veterans value and cherish our democratic process. However, VFRL will continue to call out veterans whose behavior harms the United States, while organizing veterans to continue to be of service nationwide as civilians.

Veterans for Responsible Leadership (VFRL), http://vfrl.org,  is a fully inclusive, nonpartisan organization whose mission is to preserve the integrity of American democracy against those who seek to undermine and subvert its institutions, the rule of law, and electoral system for personal or political advantage.  Its members believe that service to the country shouldn’t end when they take off the uniform , and all are asked to sign the Veteran Code, http://veterancode.org, to keep faith with their oath, their country, and their fellow veterans.

Media Contact: Jonathan Bernstein or Ellen Gustafson, 290579@email4pr.com, (720) 449-2310

 

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SOURCE Veterans for Responsible Leadership

LastObject Continues Fight Against Singe-Use With Latest Product

COPENHAGEN, Denmark, Feb 2, 2021 /PRNewswire/ — After a hugely successful 2020, LastObject is back with a new product, a tabletop version of their popular reusable tissue pack, <a target="_blank"…

COPENHAGEN, Denmark, Feb 2, 2021 /PRNewswire/ — After a hugely successful 2020, LastObject is back with a new product, a tabletop version of their popular reusable tissue pack, LastTissue.

LastTissue Big is designed to look like single-use alternatives — but is much better for the environment.

The LastTissue campaign in early 2020 raised over $800K from 14,000 backers, many of whom requested a tabletop version. In response, LastObject founder Isabel Aagaard is delivering LastTissue Big.

Ideal for using at home or the office, LastTissue Big is designed to look like its single-use alternative — the Kleenex box — but is much better for the environment. Made from 100% organic cotton, each tissue lasts 520 washes. With 18 tissues per box that means youre saving the planet from 9360 single-use tissues and their plastic packaging.

The box is made of food-grade silicone and is dishwasher-safe. It comes with a silicone barrier inside to separate the clean tissues from the dirty ones. Users pull a tissue from the top then push the used tissue inside the bottom opening. When the pack is empty, the tissues can be machine washed.

Every day 22,000 trees are cut down to supply facial tissues for The US alone. Deforestation leads to direct loss of wildlife habitat as well as climate change, soil erosion, and more. With LastTissue and LastTissue Big, LastObject aims to help alleviate this issue.

Looking ahead, Isabel Aagaards long-term goal is to eliminate single-use products altogether by creating reusable alternatives such as LastSwab, the worlds first reusable Q-tip. With three products on the market since 2019 shes already helped eliminate over 1 billion single-use items and aims to make that 50 billion by 2023.

LastTissue Big launches today on Kickstarter, backers can pre-order for as little as $53 (estimated MRP $79).

LastObject

The founder of LastObject is a designer from Copenhagen, Denmark. Frustrated by all of the single-use waste, Isabel Aagaard decided to design innovative solutions to wasteful habits that make a lasting impact. LastObject was founded in 2018 and launched its first product, LastSwab, in 2019. In 2020 LastTissue, LastRound, and LastMask x Spray were brought to life. As an eco-fighter and power-mom Isabel stands by her products and hopes to to inspire others to be the change and adapt to living sustainably.

Media Contact

Helen Sharp
Be Influential Public Relations
Helen(at)beinfluentialpr.com
713.385.3008

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SOURCE LastObject

AMC Networks y Shaftesbury llegan a una nueva asociación estratégica

– AMC Networks y Shaftesbury llegan a una nueva asociación estratégica, ampliando la audiencia global para el contenido de Shaftesbury

NUEVA YORK, NY y TORONTO, ON, 2 de febrero de 2021 /PRNewswire/ — 

– AMC Networks y Shaftesbury llegan a una nueva asociación estratégica, ampliando la audiencia global para el contenido de Shaftesbury

NUEVA YORK, NY y TORONTO, ON, 2 de febrero de 2021 /PRNewswire/ — AMC Networks, compañía de entretenimiento detrás de algunas de las marcas más populares y galardonadas en la televisión, streaming y cine, y la compañía de producción revolucionaria Shaftesbury, anunciaron hoy que han llegado a una nueva asociación estratégica. A través de su inversión en Shaftesbury, AMC Networks conseguirá acceso a la prestigiosa lista de Shaftesbury, ampliando su contenido y capacidades de desarrollo en Canadá. La consejera delegada de Shaftesbury y presidenta, Christina Jennings, seguirá propaganda su objetivo creativo de la compañía, liderando su control operativo del día a día junto al vicepresidente ejecutivo, Scott Garvie. Jennings, Garvie y el miembro del consejo de administración de Shaftesbury, Michael Levine, seguirán en el consejo de dirección de Shaftesbury. A ellos se les unirán dos nuevos directores de AMC Networks, Harold Gronenthal, vicepresidente ejecutivo de programación y marketing para AMC Networks International, y Matt Graham, responsable general del servicio de streaming de Acorn TV, propiedad de AMC Networks. Shaftesbury y sus accionistas recibirán asesoramiento sobre esta inversión estratégica por medio de RBC Capital Markets.

Shaftesbury CEO and Chairman Christina Jennings

La nueva asociación va a crear un crecimiento para la lista de contenido existente y futura de Shaftesbury para todos los géneros, creando más oportunidades de cara a los creadores canadienses frente y detrás de la cámara. La asociación también se basa en AMC Networks y en la relación de producción existente de Shaftesbury. Shaftesbury es el estudio que está detrás de algunos de los títulos más importantes de Acorn TV, incluyendo las 14 temporadas de Murdoch Mysteries. Además de Acorn TV, AMC Networks pone en marcha las marcas de entretenimiento AMC, SundanceTV, BBC America y los servicios de transmisión de rápido crecimiento AMC +, Shudder, Sundance Now y ALLBLK.

«Esta nueva asociación va a aventajarse de la amplia experiencia de AMC Networks y Shaftesbury para desplegar unas oportunidades de crecimiento importantes para el desarrollo, producción, distribución y alcance de nuestro contenido», explicó Christina Jennings, consejera delegada y presidenta de Shaftesbury. «Conseguir las historias de Canadá y el talento creativo del mercado internacional siempre ha sido la misión de Shaftesbury – esta relación nos va a proporcionar un gran avance».

«Christina cuenta con una compañía de producción de nivel mundial con un registro destacado y reputación para la creación de contenido de alta calidad que resuena en los mercados de todo el mundo», comentó Josh Sapan, director general y consejero delegado de AMC Networks. «Shaftesbury es un socio ideal para AMC Networks, al tiempo que ampliamos nuestro objetivo puesto en el contenido premium e IP para la distribución en nuestras propias plataformas, además de las terceras partes. Además, esta asociación va a proporcionar a AMC Networks capacidades mejoradas de nuestras producciones en Canadá».

ACERCA DE AMC NETWORKS

AMC Networks es una compañía global de entretenimiento conocida por su contenido popular y aclamada por la crítica. Su cartera de marcas incluye AMC, BBC AMERICA (operada por medio de una sociedad mixta con BBC Studios), IFC, SundanceTV, WE tv, IFC Films y una cifra de servicios de streaming de rápido crecimiento, incluyendo el paquete de transmisión AMC+ premium, Acorn TV, Shudder, Sundance Now y ALLBLK (denominado anteriormente «UMC»). AMC Studios, el estudio interno de la compañía, operación de traducción y distribución de la compañía, está detrás de las premiadas series y franquicias propias, incluyendo The Walking Dead, la serie con mejor clasificación en la historia del cable. La compañía pone en marcha también AMC Networks International, sus negocios de programación internacionales, además de Levity Entertainment Group, sus servicios de producción y negocios de comedia.  

ACERCA DE SHAFTESBURY

Shaftesbury es un creador y productor de prestigio de contenido original de television, cine y digital. La gama actual de Shaftesbury incluye 2 temporadas del éxito Departure for Global/Corus Entertainment, Peacock y NBC Universal, 14 temporadas de la favorita de los aficionados Murdoch Mysteries para CBC, Acorn TV y UKTV, 4 temporadas del drama de detectives Frankie Drake Mysteries para CBC y UKTV, 4 temporadas de la serie de horror aclamada por la crítica Slasher con la cuarta temporada producida para su lanzamiento en Shudder, tres temporadas de Hudson & Rex para Citytv/Rogers Media, Dead Still para RTÉ, Acorn TV, y Citytv/Rogers, y The Sounds para CBC, Acorn TV, y Sky NZ. www.shaftesbury.ca 

CONTACTO: Jane Collins, Shaftesbury, jcollins@shaftesbury.ca, 647.323.8874; Georgia Juvelis, AMC Networks, Georgia.juvelis@amcnetworks.com, 917-542-6390

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Green Roof Market to Garner $4.19 Bn, Globally, by 2027 at 15.6% CAGR: Allied Market Research

PORTLAND, Ore., Feb. 2, 2021 /PRNewswire/ — Allied Market Research recently published a report, titled, «Green Roof Market by Outlook (Extensive and Intensive), Distribution Channel (Online and Offline), and Application (Residential, Commercial, and Industrial): Global Opportunity Analysis and Industry Forecast, 2020–2027». As per the report, the global green roof industry generated…

PORTLAND, Ore., Feb. 2, 2021 /PRNewswire/ — Allied Market Research recently published a report, titled, «Green Roof Market by Outlook (Extensive and Intensive), Distribution Channel (Online and Offline), and Application (Residential, Commercial, and Industrial): Global Opportunity Analysis and Industry Forecast, 2020–2027». As per the report, the global green roof industry generated $1.45 billion in 2019, and is projected to reach $4.19 billion by 2027, growing at a CAGR of 15.6% from 2020 to 2027.

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Drivers, restraints, and opportunities

Increase in awareness regarding green roof systems, rise in the greenhouse effect, and growth in the residential construction sector drive the growth of the global green roof market. However, presence of substitutes and unfavorable climate conditions hamper the market growth. On the contrary, tax benefits offered by the government to private industries to install green roofs are expected to open lucrative opportunities for the market players in the future.

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COVID-19 scenario:

  • Due to the COVID-19 pandemic, government declared shut down of the production of various sizes of green roof systems to curb the spread of the infection.
  • The halt in international trade, ceased construction projects, and disruption in the supply chain hampered the demand for green roof systems.

The intensive segment to manifest the highest CAGR through 2027

By type, the intensive segment is expected to register the highest CAGR of 17.0% during the forecast period, owing to rapid urbanization, increase in population, and rise in disposable income. However, the extensive segment held the lion’s share in 2019, accounting for nearly four-fifths of the global green roof market, due to increase in commercial construction activities that led to high investments.

The commercial segment held the lion’s share

By application, the commercial segment dominated the market in 2019, contributing to nearly two-thirds of the global green roof market, due to rise in commercial construction activities and increase in awareness about green roof systems. However, the industrial segment is projected to register the highest CAGR of 17.1% during the forecast period, owing to expansion of the manufacturing sector in emerging countries such as India, China, and Singapore.

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Asia-Pacific to register the highest CAGR; North America would gain momentum

By region, the market across Asia-Pacific is anticipated to manifest the highest CAGR of 18.3% during the forecast period, due to rise in urbanization & industrialization in emerging countries such as India, Japan, and others. However, the global green roof market across Europe held the largest share in 2019, accounting for nearly two-fifths of the total revenue of the market, owing to increase in awareness about green roof systems among the European population and growth in standard of living. In addition, North America is expected to register a CAGR of 15.0% from 2020 to 2027.

Key market players

  • Axter Limited
  • Green Roof Blocks
  • Bauder Ltd
  • Sempergreen Group
  • Optigrun International AG
  • Barrett Company
  • American Hydrotech Inc
  • Onduline Group SAS
  • ArchiGreen Roof Ltd
  • XeroFlor North America

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Allied Market Research (AMR) is a full-service market research and business-consulting wing of Allied Analytics LLP based in Portland, Oregon. Allied Market Research provides global enterprises as well as medium and small businesses with unmatched quality of «Market Research Reports» and «Business Intelligence Solutions.» AMR has a targeted view to provide business insights and consulting to assist its clients to make strategic business decisions and achieve sustainable growth in their respective market domain.

We are in professional corporate relations with various companies and this helps us in digging out market data that helps us generate accurate research data tables and confirms utmost accuracy in our market forecasting. Each and every data presented in the reports published by us is extracted through primary interviews with top officials from leading companies of domain concerned. Our secondary data procurement methodology includes deep online and offline research and discussion with knowledgeable professionals and analysts in the industry.

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SOURCE Allied Market Research

New Report: The (Mostly Republican) Politics Of The Trillion Dollar S&P 500 Index Fund Market

MADISON, Wis., Feb. 2, 2021 /PRNewswire/ — Do you know the politics of the companies in your investment and retirement portfolios? Most people don’t because the information is not readily available. Mutual funds and exchange traded funds typically include dozens of company stocks, so figuring out the political impact of your retirement and investment money is extremely difficult.

And that is something Goods Unite Us, a Madison-based app and website…

MADISON, Wis., Feb. 2, 2021 /PRNewswire/ — Do you know the politics of the companies in your investment and retirement portfolios? Most people don’t because the information is not readily available. Mutual funds and exchange traded funds typically include dozens of company stocks, so figuring out the political impact of your retirement and investment money is extremely difficult.

And that is something Goods Unite Us, a Madison-based app and website company that sheds light on corporate money in politics, wants to change. If individuals care about being socially and politically conscious, which companies they invest in matters — a lot.

That’s why the team at Goods Unite Us spent the last few months analyzing the politics of one of the most common retirement and investment portfolio products out there: S&P 500 index funds. As their name implies, these funds include about 500 of the largest publicly-traded companies’ stocks.

The top three S&P 500 index funds have over $1.15 trillion dollars of people’s hard-earned money invested into them. (If you have a retirement or investment portfolio, you almost definitely own one of these funds.)

WHAT ARE THE POLITICS OF THE TOP THREE S&P 500 INDEX FUNDS?

Key takeaways:

  • In total, the companies whose stock are included in these three funds and their senior executives have given over $1 billion dollars to politicians and PACs during the last four federal election cycles.
  • Approximately 55% of the companies in these funds donate more to Republicans than to Democrats. Meanwhile, only 29% give more to Democrats than Republicans.
  • Using each fund’s company weightings, we estimate that a $10,000 investment into one of these funds would effectively buy about $4,000 dollars-worth of stock in Republican companies.
  • In the top three S&P 500 funds alone about $460 billion dollars is invested into Republican companies. While it’s impossible to know exactly how much of that $460 billion dollars came from people that identify as Democrats, we estimate it to be more than $100 billion dollars.

The funds analyzed were:

  • Vanguard’s S&P 500 ETF, which has over $615 billion dollars invested in it;
  • SPDR’s S&P 500 ETF Trust, which has over $320 billion dollars invested in it; and
  • iShares’ Core S&P 500 ETF, which has over $230 billion dollars invested in it.

You can access our full report by going here.

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SOURCE Goods Unite Us

Maxim Integrated Unveils Industry’s First Data Acquisition System to Achieve ASIL-D Compliance for Voltage, Current, Temperature and Communication of a Battery Management System

SAN JOSE, Calif., Feb. 2, 2021 /PRNewswire/ — Designers of automotive battery management systems (BMS) can now deliver the highest level of safety for voltage, current, temperature and communication while also saving space and reducing solution cost, with the MAX17852 14-channel, high-voltage, ASIL-D data-acquisition system from Maxim Integrated Products, Inc. (NASDAQ: MXIM). Designed for integration within electric vehicles, hybrid electric vehicles and other transportation…

SAN JOSE, Calif., Feb. 2, 2021 /PRNewswire/ — Designers of automotive battery management systems (BMS) can now deliver the highest level of safety for voltage, current, temperature and communication while also saving space and reducing solution cost, with the MAX17852 14-channel, high-voltage, ASIL-D data-acquisition system from Maxim Integrated Products, Inc. (NASDAQ: MXIM). Designed for integration within electric vehicles, hybrid electric vehicles and other transportation systems, the IC is ideal for smart junction box, 48V and other automotive battery systems which can see voltages up to 400V and beyond.   

OEMs and electric vehicle manufacturers require that all battery systems meet the highest safety requirements set by the ISO26262 guidelines. Through comprehensive diagnostics and a safety-driven architecture, Maxim Integrated designed and manufactured the MAX17852 to enable customers to design their systems to meet the highest ASIL-D standards for voltage, current, temperature and communication. The small, cost effective IC also offers the highest accuracy for delivering voltage, current and temperature data with tight time synchronization. It allows a typical cell voltage measurement of ±0.45mV at room temperature and a maximum of ±2mV error in a temperature range of 5 degrees to 40 degrees Celsius, enabling car OEMs to get the most mileage range out of their batteries. With a current sense amplifier capability of +/-300mV, and a gain setting up to 256 times and 0.3 percent current sense gain error, the MAX17852 provides the fastest, most accurate data for calculating power management, state of health and state of charge. The 14-channel battery data acquisition system integrates a current sense amplifier so that current information is acquired at the same time as cell voltage and temperature. The MAX17852 allows both hall effect sensor and shunt resistors to be used as sensing components.

Key Advantages

  • Highest Safety: ASIL-D rating for voltage, current, temperature and communication enhances safety
  • Highest Accuracy: Measurement accuracy with best current sense amplifier gain error to allow accurate, time-aligned current measurements to potentially boost mileage
  • Smaller Size: High integration enables up to 16 percent smaller size than a discrete solution to save board space
  • Lower Cost: Integrated current sense amplifier provides up to 20 percent cost savings
  • Versatility: The first device that can be adapted to many applications with voltage, current and temperature sensing

Commentary

  • «Enabling systems to achieve the highest level of safety (ASIL D) for a BMS system is really a must for consumers to feel safe in their electrified vehicles,» said Tamer Kira, executive director for the Automotive Business Unit at Maxim Integrated. «The MAX17852 is the fastest and most accurate in voltage, current and temperature measurements and that is why it is the first battery data acquisition system in the industry to achieve the highest safety rating for all the major components of a BMS system.»

Availability and Pricing

  • The MAX17852 is available at Maxim’s website for $7.52 (1000-up, FOB USA); also available from authorized distributors
  • The MAX17852EVKIT# evaluation kit is available for $250

About Maxim Integrated
Maxim Integrated, an engineer’s engineering company, exists to solve the designer’s toughest problems in order to empower design innovation. Our broad portfolio of high-performance semiconductors, combined with world-class tools and support, delivers essential analog solutions including efficient power, precision measurement, reliable connectivity and robust protection along with intelligent processing. Designers in application areas such as automotive, communications, consumer, data center, healthcare, industrial and IoT trust Maxim to help them quickly develop smaller, smarter and more secure designs. Learn more at https://www.maximintegrated.com

Contact:    

Gayle Bullock

408-464-2516

Gayle.Bullock@maximintegrated.com

 

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SOURCE Maxim Integrated Products Inc.

RedHill Biopharma anuncia valoración positiva de la futilidad del DSMB para el estudio de fase 2/3 de opaganib para la COVID-19

TEL AVIV, Israel y RALEIGH, Carolina del Norte, 2 de febrero de 2021 /PRNewswire/ — RedHill Biopharma Ltd. (Nasdaq: RDHL) («RedHill» o la «Compañía»), una compañía especializada en la biofarmacéutica, anunció hoy que el Comité de Monitoreo de Datos y Seguridad (DSMB) independiente designado para el estudio global en fase 2/3 de opaganib[1] en pacientes con COVID-19…

TEL AVIV, Israel y RALEIGH, Carolina del Norte, 2 de febrero de 2021 /PRNewswire/ — RedHill Biopharma Ltd. (Nasdaq: RDHL) («RedHill» o la «Compañía»), una compañía especializada en la biofarmacéutica, anunció hoy que el Comité de Monitoreo de Datos y Seguridad (DSMB) independiente designado para el estudio global en fase 2/3 de opaganib[1] en pacientes con COVID-19 grave recomendó de manera unánime la continuidad del estudio, después de una valoración preprogramada de futilidad de los datos no cegados para los primeros 135 pacientes tratados en el estudio, así como de la información de seguridad de los primeros 175 pacientes. 

 

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«Opaganib es un nuevo inhibidor de la esfingosina quinasa-2 (SK2) administrado por vía oral con una actividad antiviral, antiinflamatoria y antitrombótica demostrada. La recomendación positiva y unánime del DSMB es un hito importante en el progreso de nuestro programa de desarrollo para la enfermedad de COVID-19. Junto con los resultados positivos del estudio de fase 2, esta recomendación unánime del DSMB para continuar el estudio global de fase 2/3 sugiere que vamos en la dirección correcta desde una perspectiva de seguridad y eficacia», comentó Mark L. Levitt, M.D., Ph.D., director médico de RedHill. «Este es un momento particularmente difícil en la lucha contra la pandemia, con mutaciones virales que aumentan las tasas de infección e impactan muchos aspectos de la respuesta de la sociedad a la pandemia. La necesidad de terapias eficaces es clara. El mecanismo de acción de Opaganib de dirige al componente SK2 de la célula humana huésped, que está involucrado tanto en la replicación viral dentro de la célula como en las respuestas inflamatorias/inmunes posteriores. Esto significa que se espera que el opaganib mantenga su actividad independientemente de las preocupantes mutaciones en la proteína spike SARS-CoV-2. Estas mutaciones subrayan el potencial del SARS-CoV-2 para desarrollar resistencia a los mAbs antivirales directos y para afectar potencialmente la efectividad de la vacuna. Esta es una ventaja importante del opaganib ante la creciente multitud de cepas virales, y promete ser una opción de tratamiento muy necesaria que puede ayudar a que los pacientes sean desconectados del oxígeno suplementario y salgan pronto del hospital».

Esta valoración de futilidad positiva por parte del DSMB, que sugiere que el estudio global de fase 2/3 avanza como se esperaba, se suma a los datos positivos de seguridad y eficacia de primera línea del estudio de fase 2 en los Estados Unidos, en el que el opaganib demostró mejoría en la reducción del requerimiento de oxígeno al final del tratamiento, el día 14, en los resultados clave de eficacia primaria y secundaria, lo que se correlaciona con la mejoría clínica según la escala ordinal de la Organización Mundial de la Salud (OMS). Los datos de la fase 2 tampoco mostraron diferencias sustanciales de seguridad entre los brazos de tratamiento tratados con opaganib y placebo, lo que se suma a la creciente base de datos de seguridad para el opaganib. En las próximas semanas se espera un análisis completo de los datos de la fase 2, incluidos los análisis de biomarcadores virales e inflamatorios, los factores de riesgo basales y la estratificación del estándar de cuidado para el tratamiento de base, los cuales se compartirán con pares para su valoración.

En línea con la rápida evolución de la práctica clínica y las directrices para el tratamiento de pacientes hospitalizados con COVID-19, cuyo objetivo es minimizar la intubación y la ventilación mecánica de los pacientes, la variable principal del estudio global de fase 2/3 ahora es la proporción de pacientes que al día 14 logran respirar por sí solos (ya no requieren oxígeno suplementario), lo que anteriormente era una una variable clave secundaria. La intubación y la ventilación mecánica siguen siendo una variable secundaria. En consecuencia, se planea un ajuste ciego del estudio para aproximadamente 460 pacientes. En la actualidad se cuenta con aproximadamente 30 sedes para el estudio en 7 países, y durante los próximos días y semanas se agregarán más sedes y países. Para el segundo trimestre de 2021 se espera contar con datos de primera línea y aplicaciones para autorización de uso potencial en emergencias a nivel global.

Acerca de Opaganib (Yeliva®, ABC294640) 

El opaganib, una nueva entidad química patentada y primera en su categoría, es un novedoso inhibidor selectivo de la esfingosina quinasa-2 (SK2) que se administra por vía oral, con actividad dual antiviral e inflamatoria demostrada que apunta al componente celular en el huésped que se encarga de la replicación del virus, y puede reducir la probabilidad de desarrollar resistencia del virus. El opaganib también ha mostrado actividad anticancerígena y tiene el potencial de apuntar a múltiples indicaciones oncológicas, virales, inflamatorias y gastrointestinales.

El opaganib recibió la designación de medicamento huérfano de la Administración de Alimentos y Medicamentos (FDA) de los Estados Unidos para el tratamiento del colangiocarcinoma y se está evaluando en un estudio de fase 2a para pacientes con colangiocarcinoma avanzado y en un estudio de fase 2 para pacientes con cáncer de próstata. El opaganib también está siendo evaluado como tratamiento para la neumonía por COVID-19 en un estudio global de fase 2/3 y ha evidenciado señales positivas de seguridad y eficacia en los datos preliminares de primera línea de un estudio de fase 2 en los Estados Unidos.

Los datos preclínicos han demostrado las actividades antiinflamatorias, antivirales y antitrombóticas del opaganib, con el potencial de aliviar trastornos inflamatorios del pulmón, como la neumonía, y de mitigar el daño pulmonar fibrótico. El opaganib demostró una potente actividad antiviral contra el SARS-CoV-2, el virus que causa la COVID-19, mediante la inhibición total de la replicación viral en un modelo in vitro de tejido broncopulmonar humano. El opaganib también demostró una reducción en la longitud del coágulo sanguíneo, el peso y la puntuación total del trombo en un modelo preclínico de síndrome de dificultad respiratoria adquirida. Adicionalmente, estudios preclínicos in vivo[2] han demostrado que el opaganib disminuye la tasa de letalidad por infección viral de influenza y mejora del daño pulmonar inducido por Pseudomonas aeruginosa mediante la reducción de los niveles de IL-6 y TNF-alfa en los fluidos de irrigación broncoalveolares.

El opaganib fue desarrollado originalmente por Apogee Biotechnology Corp. en los Estados Unidos y terminó múltiples estudios preclínicos con éxito en modelos oncológicos, inflamatorios, gastrointestinales y radioprotectores, así como un estudio clínico de fase 1 en pacientes de cáncer con tumores sólidos avanzados y un estudio de fase 1 adicional en pacientes con mieloma múltiple.

El desarrollo del opaganib ha recibido apoyo de subvenciones y contratos de agencias gubernamentales estatales y federales de los Estados Unidos, otorgadas a Apogee Biotechnology Corp., que incluyen la NCI, BARDA, el Departamento de Defensa de los Estados Unidos y la oficina de Desarrollo de Productos Huérfanos de la FDA.

Los estudios en curso con opaganib están registrados en la página www.ClinicalTrials.gov, un servicio web del Instituto Nacional de Salud de los Estados Unidos, que otorga acceso público a la información sobre estudios clínicos con financiación pública y privada.   

Acerca de RedHill Biopharma    

RedHill Biopharma Ltd. (Nasdaq: RDHL) es una compañía especializada en biofarmacéutica centrada principalmente en enfermedades gastrointestinales e infecciosas. RedHill promueve los medicamentos gastrointestinales, Movantik® para el estreñimiento inducido por opioides en adultos[3]Talicia® para el tratamiento de infección por  Helicobacter pylori (H. pylori) en adultos[4]Aemcolo® para el tratamiento de diarrea del viajero en adultos[5]. Los programas clave de investigación clínica en desarrollo en última etapa de RedHill incluyen los siguientes: (i) RHB-204, con un estudio de fase 3 en curso para enfermedad pulmonar por micobacterias no tuberculosas (NTM); (ii) opaganib (Yeliva®, ABC294640), un inhibidor selectivo SK2 primero en su categoría que apunta a múltiples indicaciones con un programa de fase 2/3 para la COVID-19 y estudios de fase 2 para cáncer de próstata y colangiocarcinoma en curso; (iii) RHB-107 (upamostat), un inhibidor de la serina proteasa con un estudio de pase 2/3 planeado para COVID-19 sintomático y dirigido también a múltiples enfermedades gastrointestinales inflamatorias y cáncer (iv) RHB-104, con resultados positivos de un primer estudio de fase 3 para la enfermedad de Crohn; (v) RHB-102 (Bekinda®), con resultados positivos de un estudio de fase 3 para gastroenteritis aguda y gastritis, y resultados positivos de un estudio de fase 2 para IBS-D; y (vi) RHB106, una preparación encapsulada para el intestino. En www.redhillbio.com hay disponible más información acerca de la compañía / https://twitter.com/RedHillBio.

NOTA: Este comunicado de prensa, presentado con fines prácticos, es una versión traducida del comunicado de prensa oficial publicado por la compañía en inglés. Para leer el comunicado de prensa completo en inglés, incluido el descargo de responsabilidades de las declaraciones prospectivas, por favor, visite: https://ir.redhillbio.com/press-releases

 

Contacto de la compañía: 

Adi Frish

Director ejecutivo de Corporate & Business Development

RedHill Biopharma

+972-54-6543-112

adi@redhillbio.com 

 

Contacto de prensa (EE.UU.): 

Bryan Gibbs

Vicepresidente

Finn Partners

+1 212 529 2236

bryan.gibbs@finnpartners.com 

[1] Opaganib es un nuevo fármaco en investigación, no disponible para distribución comercial.

[2] Xia C. et al. La inhibición transitoria de esfingosina quinasa otorga protección contra el virus de la influenza A en ratones infectados. Antiviral Res. 2018 Oct; 158:171-177. Ebenezer DL et al. La Pseudomonas aeruginosa estimula la generación nuclear de la esfingosina-1-fosfato y la regulación epigenética del daño inflamatorio al pulmón. Thorax. 2019 Jun;74(6):579-591.

[3] La información completa de prescripción de Movantik® (naloxegol) se encuentra disponible en: www.Movantik.com

[4] La información completa de prescripción de Talicia® (omeprazol magnesio, amoxicilina y rifabutina) se encuentra disponible en: www.Talicia.com.  

[5] La información completa de prescripción de Aemcolo® (rifamicina) se encuentra disponible en: www.Aemcolo.com.

Logotipo: https://mma.prnewswire.com/media/1334141/RedHill_Biopharma_Logo.jpg 

 

FUENTE RedHill Biopharma Ltd.