TORONTO, Aug. 5, 2020 /PRNewswire-PRWeb/ — One of the challenges in clinical flow cytometry is limited stability of fresh whole blood samples. It is essential to have sufficient sample stability for flow cytometry analysis in clinical trials, as this allows for transportation of samples from clinical sites to the flow cytometry laboratory, and enables batching of samples, thereby increasing consistency of data and cost-effectiveness of the study.
Clinical studies can contain flow analyses varying from straight-forward cell subset characterization to complex target engagement and intracellular phosflow assays. For late phase clinical studies that require flow cytometry analysis often include shipment of samples from multiple different sites, it is essential to address sample stability during method development and validation of the applied flow cytometry assays. There are several techniques and methods available for extending stability of flow cytometry samples including availability of fixative-containing commercial blood collection tubes, freezing whole blood and applying lyse/fix and freezing methods after sample collection for storage up to several weeks. These approaches have been successfully implemented in clinical studies, enabling complex but efficient flow cytometry analysis in multi-site clinical studies. This webinar will address several strategies for extending stability of flow cytometry samples, and implementation thereof in clinical studies.
Join Amanda Hays, Ph.D., Associate Director of Bioanalytical Science, PRA Health Sciences and Henko Tadema, Ph.D., Associate Director of Bioanalytical Science, PRA Health Sciences in a live webinar on Wednesday, August 26, 2020 at 11am EDT (4pm BST/UK).
For more information or to register for this event, visit Approaches For Extending Sample Stability For Flow Cytometry Analysis In Clinical Trials.
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