Autor: venred

BALTIMORE, Aug. 5, 2020 /PRNewswire/ — Sysmex-Inostics, Inc., a global leader and pioneer in blood-based circulating tumor DNA (ctDNA) analysis for oncology, today announces the publication of a clinical study evaluating the performance of plasma RAS mutation testing with OncoBEAM RAS CRC as compared to standard of care tissue-based RAS testing in the United Kingdom (UK).

OncoBEAM RAS CRC is a CE-IVD test that uses BEAMing technology, an enhanced digital PCR method optimized for high sensitivity blood-based mutation detection for metastatic colorectal cancer (mCRC) patients. This is the first study of its kind in the UK with confirmatory testing performed across laboratories certified to run the OnocBEAM RAS CRC test. Investigators also utilized the highly sensitive nature of OncoBEAM testing to also explore the clinical value of detecting changes in plasma RAS mutation status in patients treated with anti-EGFR antibody therapy.

The overall percent agreement between the OncoBEAM assay and tissue-based testing for RAS mutations was 86.0% (86/100), with a 100% reproducibility of test results between three labs located in the UK, Germany, and Japan. This demonstrates that blood-based testing with an appropriate and well validated assay can serve as an alternative to tissue-based testing and can improve access to precision medicine globally.

Colorectal cancer (CRC) continues to be one of the leading causes of cancer-related deaths globally. Anti-EGFR monoclonal antibodies have demonstrated significant improvements in survival of patients with wild-type RAS tumors mCRC. However, tissue-based biomarker testing has been shown to present several challenges, such as tumor molecular heterogeneity, poor tissue quality, and logistical issues, which can contribute to delays in treatment initiation. Importantly, as patients undergo treatment with targeted therapies, insight into changing tumor molecular dynamics would require repeat tissue biopsies, which is not practical in routine clinical management. Since mCRC patients already undergo regular blood draws throughout treatment; testing with the OncoBEAM RAS assay can deliver valuable insights into tumor response.

The ability to draw serial blood samples and perform OncoBEAM ctDNA longitudinal analyses of RAS mutant allelic fraction (MAF) variation before and during anti-EGFR therapy provides opportunities to identify emerging RAS mutant clones early during treatment. This minimally invasive approach provides better visualization of treatment responses and failures, enabling personalized therapy approaches for mCRC patients, with the goal of improving outcomes. The lead and senior authors of the study, Dr. Theodora Germetaki and Dr. Mark Saunders, Department of Medical/Clinical Oncology, The Christie Hospital, Manchester, UK conclude: «We showed that 20% of patients showed a change in their RAS mutational status during treatment. These results demonstrate there is an opportunity to more precisely understand an individual patient’s tumor response using longitudinal plasma testing in order to establish new clinical decision points for the management of patients receiving EGFR inhibitor therapy.» Ongoing studies are exploring the outcomes and cost-effectiveness of OncoBEAM RAS testing to guide the management of anti-EGFR treatment in mCRC patients.

Overall, this study shows the value of an ultrasensitive OncoBEAM liquid biopsy RAS test in overcoming sampling bias associated with tissue biopsy to enable rapid turn-around time of molecular test results for more timely initiation of first-line treatment and early detection of RAS mediated resistance in patients receiving anti-EGFR therapy.

The publication, titled «Blood-based RAS mutation testing: concordance with tissue-based RAS testing and mutational changes on progression,» was published in Future Oncology July 27, 2020, by Theodora Germetaki, et al. https://www.futuremedicine.com/doi/10.2217/FON-2020-0523.

About Sysmex Inostics

Sysmex Inostics, a subsidiary of Sysmex Corporation, is a molecular diagnostic company that is a pioneer in blood-based cell-free tumor DNA (ctDNA) mutation detection in oncology utilizing highly sensitive technologies such as OncoBEAM^TM (digital PCR) and SafeSEQ (NGS). These technologies were initially developed by experts at the Johns Hopkins School of Medicine over a decade ago and this deep expertise in ctDNA analysis extends to the core of Sysmex Inostics’ capabilities for technology development and implementation.

With more than 10 years’ of experience in liquid biopsy Sysmex Inostics is a trusted partner to leading pharmaceutical companies, advancing their efforts to bring the most effective personalized cancer therapies to global markets, from discovery through companion diagnostics.

Sysmex Inostics’ OncoBEAM^TM and SafeSEQ services are readily available to support clinical trials and research in oncology. In addition, OncoBEAM^TM tests are available through a CLIA-certified laboratory for routine clinical analysis as well as distributed kit products in the EU.

Sysmex Inostics’ European headquarters for research & development GCP laboratory testing are located in Hamburg Germany; Sysmex Inostics’ US headquarters and CLIA-certified and GCP Clinical Laboratory is located in Baltimore, Maryland.

For more information refer to www.sysmex-inostics.com or email info@sysmex-inostics.com.

Contact:

Sysmex Inostics
Press Release
Phone: +49-(0)-40-3259070
Mail: info@sysmex-Inostics.com

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SOURCE Sysmex Inostics GmbH

SACRAMENTO, Calif. and MINNEAPOLIS, Aug. 5, 2020 /PRNewswire/ — With Covid-19 putting increasing pressure on parents and educators to come up with viable solutions for supporting distance learning, Minneapolis based Kwikbit Inc., today announced that it was partnering with the State of California’s Department of Education to bring broadband access to low income communities in the Corning Unified School District. Kwikbit Inc., a world leader in 60GHz wireless will be extending Internet access from the district’s schools to neighborhood multifamily housing complexes. 

«Kwikbit is stepping up to serve students and families in Corning, and we applaud Kwikbit’s efforts to bridge the digital divide in California,» said the California Governor’s Office.

«The lack of internet access in these communities is quite severe. It really shows the digital divide that we have in this country, and needless to say makes it difficult for educators to do their jobs in these trying times. The problem has to be solved quickly and at a reasonable price. Traditional approaches, such as fiber and cable are either too expensive, or too slow,» said Joe Costello, CEO of Kwikbit.

«The digital divide is real in Corning and as such, the need for scalable and affordable technology solutions is pronounced. We are very pleased to support a pilot around this promising technology,» said Corning Superintendent Rick Fitzpatrick. Corning’s technology director Matt Jardin added, «the performance and ease of install is remarkable, this is a very impressive solution.» 

Kwikbit’s multi-gigabit scalable wireless network solution brings fiber-like performance at small fraction of the cost and time to deploy. 

«Kwikbit’s solution is a technological breakthrough and the underlying economics are essential to address the digital divide,» said Lawrence Alioto, Senior Advisor to Kwikbit. «The core challenges for widespread high-speed connectivity are cost, time to deploy, and disruption. Kwikbit’s solution addresses all three,» Alioto went on to say.

About Kwikbit:
Kwikbit (kwikbit.com) is a wireless technology company based in Minneapolis, MN. Kwikbit’s specialized 60 GHz millimeter wave radios driven by their cloud and edge automation tools enable the rapid deployment of multi-gigabit wireless networks when and where they’re needed. Twitter:  @kwikbit  LinkedIn: https://www.linkedin.com/company/kwikbit

 

 

 

View original content:http://www.prnewswire.com/news-releases/kwikbits-60-ghz-wireless-deployed-by-state-of-californias-department-of-education-in-covid-19-fight-301106333.html

SOURCE Kwikbit, Inc.

WASHINGTON, Aug. 5, 2020 /PRNewswire-PRWeb/ — The secret to good sleep is temperature regulation. Learning from the science of sleep, the team at restlab has engineered the Equilibrium Sleep Set — technical sleepwear to help deliver the perfect night’s rest.

To achieve the best in performance and comfort, the Equilibrium is made with re-engineered silk. Using an in-house process, restlab developed a fabric with a highly breathable weave but is also a low conductor of heat. As a result, the Equilibrium provides ventilation, but also helps trap just the right amount of body heat as the wearer’s temperature drops through the night — creating the perfect micro-climate for sleep.

The Equilibrium has also addressed the impracticalities of silk to deliver not just performance and comfort, but also to meet the lifestyle demands of the modern man and woman. Unlike most delicate silk garments, the Equilibrium’s re-engineered silk is machine washable. It’s also enhanced with stretch so it doesn’t restrict movement both in and out of bed. Lastly, it’s engineered with a matte finish — without the shine common to silk fabric — for a modern and gender-neutral look.

The Equilibrium was initially launched in March as a Kickstarter campaign but was quickly hit by the COVID-19 pandemic. Though the odds were against the team, the Equilibrium ultimately had a small but successful campaign thanks to the support of the Kickstarter community.

Today, restlab is launching the Equilibrium to the general public on its own website – http://www.therestlab.com. Customers can pre-order the Equilibrium at 36% off the normal retail price until the end of August 2020.

About restlab
Sleep is critical to our overall health and well-being. But in today’s modern, high-stress society, it often takes the backseat. restlab was founded with the vision of helping people improve their wellbeing through better rest.

Ben and Shirley, the co-founders of restlab, met while developing and launching new products for Fortune 500 companies. Burned out and sleep deprived, they wanted to channel their energy toward creating meaningful products that could help others like them slow down and truly rest. They began work on restlab in 2018, relying on their own savings, angel investors, and grassroots fundraising to get their venture off the ground.

 

SOURCE restlab

IRVINE, Calif., Aug. 5, 2020 /PRNewswire-PRWeb/ — ABSTRAX, an industry leader in the study and production of cannabis and botanically-derived terpenes, has successfully passed the rigorous approval process set forth by the Alcohol and Tobacco Tax and Trade Bureau (TTB). Now, ABSTRAX’s aroma and flavor-rich terpene blends can be used in cutting-edge alcoholic beverage formulations by brands seeking «functional» aromas and flavors for their products to enhance the consumer experience.

«This is an exciting moment for our team,» says T.J. Martin, Director of Research and Development at ABSTRAX. «We worked around the clock to make this happen, as the certification process is quite intensive.»

According to US regulations, the TTB is given the authority to tax alcohol and tobacco containing products. Thus, all alcohol containing beverages must have their formulations approved by the TTB, which means that all ingredients they use must also be approved in order for a beverage to be approved for sale domestically.

«We were thrilled to see our hard work pay off,» says Martin. «Now our cannabis inspired terpenes (all of which are THC, cannabis, and hemp-free) can be added to alcoholic beverages including beers, liquors, sparkling seltzers, mixed drinks, and, and more.»

For ABSTRAX, the TTB approval process worked as follows:

1. The team was required to submit all formulas to the TTB in order to be granted a submission account.

2. Once the account was granted, ABSTRAX was then able to submit its individual flavors for approval. The process required that specific rules and regulations surrounding naming conventions, ingredient usage levels, accepted ingredients, ingredient status (synthetic vs natural and what constitutes a natural designation) were carefully followed.

3. Once each sample was received, it was analyzed by the TTB’s beverage lab team, along with ABSTRAX’s application.

4. The TTB’s team then requested edits and provided comments on each formulation, and once all edits/comments were addressed, the samples and application were reviewed to determine if they met the TTB’s needs and requests.

5. When a flavor was approved, a Flavor Ingredient Data sheet was generated (aka FIDS) and was approved for use in alcoholic beverage applications.

ABSTRAX is now one of a few innovative terpene focused flavor houses in the world that offers one-of-a-kind TTB approved terpene flavorings and custom formulations including but not limited to; Gelato, Clementine, King Louie XIII, SFV OG, Gelato, Jack Herer, Master Kush, Mango, Strawberry Fruit, Mimosa, and Pineapple Express.

We are now working with a range of beverage companies including craft breweries and distilleries to develop custom flavor systems and complete beverage formulas using our terpenes as key ingredients to develop very unique and new functional beverage products. Our clients can now leverage our ingredients to create very dynamic beverages with more complex cannabis notes that were previously unachievable.

«We look forward to continuing our terpene research program and exploring the range of many benefits surrounding terpenes and their impact on flavor and aroma formulations. We can now design beer and alcohol beverages using specific dominant terpenes and more complex formulas to achieve positive benefits for the mood and body — to help achieve the ultimate beverage experience,» says Max Koby, CEO and Co-founder at ABSTRAX.

About ABSTRAX
Leveraging its proven background in cannabis research, ABSTRAX is the leader in the research, development, and production of botanically-derived and cannabis-inspired terpenes that create unforgettable sensorial experiences. Headquartered in California, the company owns and operates a state-of-the-art type 7 licensed research and manufacturing lab where it’s award-winning product developers and scientists leverage the most advanced strain analysis technology to extract and study aroma compounds via three-dimensional analysis, allowing for each and every compound within a plant to be named and studied. The company has partnered with many of the best cultivators in the industry to study their cannabis profiles and create the world’s most advanced terpene formulations. As a result of its efforts, ABSTRAX offers the largest terpene catalogue of the most popular strains – botanically-derived terpene blends and isolates native to cannabis. These ingredients, also known as functional flavors and aromas, are used in vapes, concentrates, edibles, beer, essential oils, fragrances, cosmetics, topicals, tinctures, alcohol, food and beverage, personal care, and more. The company works with internationally recognized brands and provides unparalleled cannabis research, innovation, and custom formulations to create products that engage and thrill consumers. ABSTRAX also devotes significant resources to developing the highest terpene standards and best practices in the industry. The company has developed a robust quality management system including Gas Chromatography analysis and molecular distillation of natural ingredients to achieve the highest purity standards. Investigating and ensuring that ingredients used in its own products, and products within its industry, are safe for consumption. The terpene industry is a rapidly growing segment of the global flavor and fragrance market, which is expected to grow to $35 billion by 2024. This market segment includes the cannabis, CBD, skincare, cosmetics, health and wellness, food and beverage industries. For more information, visit AbstraxTech.com.

 

SOURCE ABSTRAX

LOS ANGELES, Aug. 5, 2020 /PRNewswire-PRWeb/ — A Gartner report titled Hype Cycle for Natural Language Technologies, 2020 (ID: G00467879) (Gartner subscription required) names Behavioral Signals as a Sample Vendor in Emotion AI. Analysts Bern Elliot, Anthony Mullen, Adrian Lee, and Stephen Emmott authored the report published on July 6, 2020.

The report classifies Emotion AI’s benefit rating as «transformational», the highest rating in the Priority Matrix for Natural Language Technologies, 2020, with a five to ten-years to mainstream adoption rate. Natural language process (NLP), Large-Scale Pretrained Language Model, Natural Language Processing(NLP) and Natural Language Understanding also have similar adoption rates. Emotion AI technology is categorized as «on the rise» and according to the report, «Emotion AI technologies have already been adopted by various business functions in different industries, including call centers, PARs and high-end cars.»

Behavioral Signals excels at distinguishing behavioral signals in speech data with its proprietary deep learning technology. Call centers are a business sector that has adopted voice-based emotion AI for intelligent routing to increase better customer experience. A previous Gartner report titled 3 Best Practices for Product Managers to Drive Adoption of Emotion AI Technology (ID: G00717124) also recognizes Behavioral Signals.

«We’ve reached a turning point in emotion AI technology adoption as we provide safer, more robust, and more accurate solutions to understand human behavior,» says Rana Gujral, CEO of Behavioral Signals. «As the emerging industry matures, data becomes stronger, and more awareness is created by reports such as this, the adoption speed and understanding of the benefits of systems to act more sympathetically will naturally increase.»

Gartner, Hype Cycle for Natural Language Technologies, 2020, Bern Elliot et Al, 6 July 2020 Gartner, 3 Best Practices for Product Managers to Drive Adoption of Emotion AI Technology, Annette Zimmermann, Brian Doherty, 11 June 2020.

Gartner does not endorse any vendor, product or service depicted in its research publications, and does not advise technology users to select only those vendors with the highest ratings or other designation. Gartner research publications consist of the opinions of Gartner’s Research & Advisory organization and should not be construed as statements of fact. Gartner disclaims all warranties, expressed or implied, with respect to this research, including any warranties of merchantability or fitness for a particular purpose.

About Behavioral Signals
Founded in 2016, Behavioral Signals enhances communication between humans and human-to-machine by deducing intelligent and actionable insights from voice using deep learning and NLP. Behavioral Signals offers a new level of customer understanding and leverages its advanced acoustics engine to not only discover genuine emotion but also predict the speaker’s intent via behavioral analysis. Offices are in Europe and Los Angeles, CA. https://behavioralsignals.com/

 

SOURCE Behavioral Signals

WATERLOO, Ontario, Aug. 5, 2020 /PRNewswire-PRWeb/ — Siborg Systems Inc. is hosting a sale on their online store and other sales channels. The sale will include LCR-Reader-MPA devices, including the base model, MPA BT with Bluetooth and MPAL Low Frequency, LCR-Reader models, and Smart Tweezers multimeters, including the bluetooth model ST5S-BT.

Siborg offers testing and debugging tools for Surface Mount Technology that combine a powerful multimeter with a set of tweezer probes. LCR-Reader has become Siborg’s best selling device since its release in 2014. The 1 oz. device has a 0.5% basic accuracy and is able to identify components and select the best test parameters before testing. All of Siborg’s devices come with sharp, gold-plated tweezer tips that can hold components up to 0204 size.

Siborg offers a wide range of test devices for Surface Mount Technology; their design combines a set of tweezer probes built into a compact yet powerful multimeter. The LCR-Reader line of devices has significantly grown since its debut in 2014. Each device is able to identify components and determine the best test parameters to use to provide high accuracy results. Users aren’t required to set-up measurements between components and can grasp and hold components without the use of long wire leads. The flagship device, the LCR-Reader is able to test with 0.5% basic accuracy, but users are only able to change the test mode.

The LCR-Reader-MPA has the widest range of features and the highest basic accuracy at 0.1%. The MPA’s features include voltage/current measurement, diode/LED test, oscilloscope mode, frequency meter, Super Cap testing up to 680 mF, pulse counting, AC/DC voltage measurements, and more. One of the main features of the MPA is the ability to test components using a 100 kHz test frequency that allows for 1 nH resolution and a 0.01 pF resolution for capacitance.

There are 3 different models of MPA available; the base model, a low-frequency model and the Bluetooth model. The low-frequency model has less test frequencies, ranging from 100 Hz to 10 kHz. The Bluetooth enabled model allows users to remotely record measurement values in real-time using PC or Android. These values can be saved into a database or file for later analysis. Users are also able to set profiles that grant a pass or fail to the component depending on if it meets the parameters set.

Features on LCR-Reader-MPA:

• 0.1% basic accuracy
• LCR/ESR, LED/Diode testing
• 3 signal test levels of 0.1, 0.5, and 1.0 Vrms
• Easy open/short calibration
• 100 kHz test signal level
• Large and Super Large Capacitance testing up to 640 mF
• Oscilloscope mode
• NIST Traceable calibration certificate (available for LCR-Reader-MPA Pro, Smart Tweezers and LCR-Reader-Pro)

The Smart Tweezers device is the basis for all other tweezer-meters. The Smart Tweezers ST-5S has a 0.2% basic accuracy, fully automatic testing for LCR/ESR, Diode polarity/short testing and more. There is a Bluetooth enabled model of Smart Tweezers also available that, much like LCR-Reader-MPA BT, is able to remotely record values and offers the same testing profiles.

Siborg’s up to 30% discount sale is starting August 10 and ending August 31st at 11:59 PM EST on the LCR-Reader Store, and Siborg’s sales channels in Europe and North America

Some discounts will also be offered by our international representatives:

China
AI-ROX Polytronics (Shenzhen) Co., Ltd
Tongtai Times Square, Fuhai Street, Baoan District, Shenzhen, 518100

Weifang Co.
Rm 403, Building 1, No.1566 Yinfeng Road, Weifang, Shandong, 261000
Phone:8618606367927

USA
Bokar International
650 Scranton Pocono Hwy, Covington Twp., PA, 18444
Phone:(570) 842-2812
Fax:(570)842-4290

Japan
Van Device Co.Ltd
Yubinbango 9-10 Studio Nihonbashi, Building 202, Nihonbashi, Chuo-ku, Tokyo boat-cho, 103-2204
Phone:+81-03-5652-2888
Fax:+81-03-5652-2889

Newly Tsuchiyama Co. Ltd. East Japan Operations
Lions Building Musashikosugi 204, 915-8 Shin-Maruko-cho, Nakahara-ju, Kawasaki-shi, Kanagawa-ken, 211-0005
Phone:+81-44-738-6870
Fax:+81-44-738-6815

Russia
SPE Group
4a Inzhenernaya Street, Suite 212
Novosibirsk
Phone:(383) 330-82-95
E-mail: fedorov (at) spegroup (dot) ru

Sanata-Tech
22 Zvenigorodskaya Street, Unit 051, Saint Petersburg
Phone:+7 (812) 983-94-50, +7 (812) 917-85-84
Fax:+7 (812) 712-34-00

India
Advance Tech Services
709-710, DT-ITL Towers, B-8, Netaji Subhash Place, Pitampura, New Delhi, 110034
Phone:+91-11-47002024
Fax:+91-11-47002029

Indonesia
CV. KT. International
Klomplek Dian Centre, Blok C. No.12, Nagoya Batam
Phone:(62)778 432976/ 778 432986 / 812 7027699
Fax:(62)778 422731

Malaysia
CF System technology Sdn Bhd
No. 43 & Jalan Section 1-28, Taman Kajang Utama, Kajan Selangor Darul Ehsan, 43000
Phone: 603-87405207
Fax:603-87374986

Lithuania
Lokmita
Taikos 141, Kaunas LT-51132
Phone: +370 37 351 729
Fax: +370 37 351 729

Netherlands
PrintTec b.v.
De Aaldor 32, 4191 PC Geldermalsen
Phone:+31-(0)-345-745911
Fax:+31-(0)-345-745910

Vietnam
V-Proud Joint Stock Company
No.62-Alley 8-11-36, Le Quang Dao Street, Phy Do Ward, Nam Tu Liem District, Hanoi
Phone:+84 4 3224 2295
Fax:+84 4 3224 2297

LIDIN Co., Ltd.
487 Cong Hoa Street, Ward 15
Tan Binh District, Ho Chi Minh City
VietNam 700000
Tel. +84-28-36016797

Indochina Equipment and Accessories Joint Stock Company
No.1-LK6B, MoLau Urban, HaDong Dist., Hanoi
Phone:(+84) 4-7-303-566
Fax:(+84) 4-7-303-4666

 

SOURCE Siborg Systems Inc.